Investigation of mechanisms that mediate reactive hyperaemia in guinea-pig hearts: role of KATP channels, adenosine, nitric oxide and prostaglandins
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منابع مشابه
The Role of Nitric Oxide and Prostaglandins in the Effect of Adenosine on Contractility, Heart Rate and Coronary Blood Flow in Guinea Pig Isolated Heart
It is a well-established fact that adenosine and its receptor subtypes (A 1 and A ) are involved in changes of contractility, heart rate and coronary blood flow (CBF) under different circumstances. This study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. For this purpose, Nitro-L-Arginine methyl ester (L-NAME), and indomethacin as inhibit...
متن کاملthe role of nitric oxide and prostaglandins in the effect of adenosine on contractility, heart rate and coronary blood flow in guinea pig isolated heart
it is a well-established fact that adenosine and its receptor subtypes (a 1 and a ) are involved in changes of contractility, heart rate and coronary blood flow (cbf) under different circumstances. this study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. for this purpose, nitro-l-arginine methyl ester (l-name), and indomethacin as inhibit...
متن کاملRole of nitric oxide in reactive hyperemia of the guinea pig heart.
To evaluate the role of nitric oxide (NO) in the flow response after brief coronary arterial occlusion, NO formation by the isolated guinea pig heart was assessed by a specific difference spectrophotometric assay. Release of NO under basal conditions was 121.8 +/- 10.5 pmol x min-1 and increased to 211.1 +/- 16.8 pmol x min-1 after 60 seconds of coronary occlusion. Simultaneously, release of cG...
متن کاملAdenosine-induced hyperpolarization in guinea pig coronary artery involves A2b receptors and KATP channels.
The role of P1 purinoceptor subtypes, the adenylyl cyclase (AC) pathway, and ATP-sensitive K+(KATP) channels in adenosine (Ado)-induced membrane hyperpolarization was investigated in isolated segments of the guinea pig coronary artery using conventional microelectrode techniques. Ado (1-100 μM) elicited concentration-dependent hyperpolarization (half-maximal effective concentration 7.5 ± 0.5 μM...
متن کاملSevoflurane enhances ethanol-induced cardiac preconditioning through modulation of protein kinase C, mitochondrial KATP channels, and nitric oxide synthase, in guinea pig hearts.
BACKGROUND Volatile anesthetics and regular ethanol consumption induce cardioprotection mimicking ischemic preconditioning. We investigated whether sevoflurane enhances ethanol preconditioning and whether inhibition of protein kinase C (PKC) and mitochondrial K(ATP) channels attenuated this enhanced cardioprotection. The effects of regular ethanol consumption on expression of inducible (iNOS) a...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2001
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0703929